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RT or No RT Following Chemotherapy in Treating Patients With Stage III/IV Hodgkin's Disease
Sponsor: European Organisation for Research and Treatment of Cancer - EORTC
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining radiation therapy with combination chemotherapy may kill more tumor cells. PURPOSE: Randomized phase III trial to compare the effectiveness of radiation therapy with no radiation therapy following chemotherapy in treating patients with stage III or stage IV Hodgkin's disease.
Official title: Phase III Randomized Trial of Adjuvant Involved-Field Radiotherapy vs No Adjuvant Therapy Following Remission Induction With MOPP/ABV Hybrid Chemotherapy in Patients With Stage III/IV Hodgkin's Disease
Key Details
Gender
All
Age Range
15 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
615
Start Date
1989-09
Completion Date
Not specified
Last Updated
2025-08-05
Healthy Volunteers
No
Conditions
Interventions
bleomycin sulfate
doxorubicin hydrochloride
mechlorethamine hydrochloride
prednisone
procarbazine hydrochloride
vinblastine sulfate
vincristine sulfate
low-LET cobalt-60 gamma ray therapy
low-LET photon therapy
radiation therapy
Locations (56)
Algemeen Ziekenhuis Middelheim
Antwerp, Belgium
A.Z. St. Jan
Bruges, Belgium
Hopital Universitaire Erasme
Brussels, Belgium
C.H.U. Saint-Pierre
Brussels (Bruxelles), Belgium
Institut Jules Bordet
Brussels (Bruxelles), Belgium
Centre Hospitalier Universitaire Brugmann
Brussels (Bruxelles), Belgium
Centre Hospitalier Universitaire de Tivoli
La Louvière, Belgium
U.Z. Gasthuisberg
Leuven, Belgium
U.Z. Sint-Rafael
Leuven, Belgium
National Cancer Institute of Egypt
Cairo, Egypt
Institut Bergonie
Bordeaux, France
Centre Regional Francois Baclesse
Caen, France
Centre Hospitalier General
Compiègne, France
Centre Georges-Francois Leclerc
Dijon, France
Centre Leon Berard
Lyon, France
Hopital Edouard Herriot
Lyon, France
Centre Antoine Lacassagne
Nice, France
Hotel Dieu de Paris
Paris, France
Hopital Saint Antoine
Paris, France
Hopital Cochin
Paris, France
Hopital Necker
Paris, France
Hopital Jules Courmont - Centre Hospitalier Lyon Sud
Pierre-Bénite, France
Hopital Sud
Rennes, France
Centre Henri Becquerel
Rouen, France
Centre Medico-Chirurgical Foch
Suresnes, France
Centre Alexis Vautrin
Vandœuvre-lès-Nancy, France
Institut Gustave Roussy
Villejuif, France
Zentralkrankenhaus
Bremen, Germany
Centro di Riferimento Oncologico - Aviano
Aviano, Italy
Dipartimente di Oncologia di Torino
Turin (Torino), Italy
Leyenburg Ziekenhuis
's-Gravenhage (Den Haag, the Hague), Netherlands
Groot Ziekengasthuis 's-Hertogenbosch
's-Hertogenbosch, Netherlands
Medisch Centrum Alkmaar
Alkmaar, Netherlands
Antoni van Leeuwenhoekhuis
Amsterdam, Netherlands
Integraal Kankercentrum Amsterdam
Amsterdam, Netherlands
Slotervaart Ziekenhuis
Amsterdam, Netherlands
Onze Lieve Vrouwe Gasthuis
Amsterdam, Netherlands
Streekziekenhuizen Gooi-Noord
Blaricum, Netherlands
Catharina Ziekenhuis
Eindhoven, Netherlands
Medisch Spectrum Twente
Enschede, Netherlands
De Wever Ziekenhuis
Heerlen, Netherlands
Radiotherapeutisch Instituut
Leeuwarden, Netherlands
Leiden University Medical Center
Leiden, Netherlands
Integraal Kankercentrum West
Leiden, Netherlands
Academisch Ziekenhuis Maastricht
Maastricht, Netherlands
St. Radboud University Hospital
Nijmegen, Netherlands
University Hospital - Rotterdam Dijkzigt
Rotterdam, Netherlands
Rotterdam Cancer Institute
Rotterdam, Netherlands
Sophia Ziekehuis
Zwolle, Netherlands
Maritime Hospital
Gdynia, Poland
Jagiellonian University
Krakow (Cracow), Poland
Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology
Warsaw, Poland
Hospitais da Universidade de Coimbra (HUC)
Coimbra, Portugal
Instituto Portugues de Oncologia de Francisco Gentil
Lisbon, Portugal
Instituto Portugues de Oncologia do Porto
Porto, Portugal
Institute of Oncology, Ljubljana
Ljubljana, Slovenia