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Phenotype/Genotype Correlations in Movement Disorders
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)
Summary
The goal of this protocol is to identify families with inherited movement disorders and evaluate disease manifestations to establish an accurate clinical diagnosis by using newest technological advances and investigate the underlying molecular mechanisms. Studies of inherited movement disorders in large families with good genealogical records are especially valuable. Patients with diseases of known molecular basis will be genotyped in order to investigate phenotype/genotype correlation. Patients with disease of unknown or incomplete genetic characterization will be studied with a hope of contributing to the identification of specific disease-causing genes and genetic mechanisms responsible for a specific disorder.
Key Details
Gender
All
Age Range
2 Years - 100 Years
Study Type
OBSERVATIONAL
Enrollment
2500
Start Date
2001-10-22
Completion Date
Not specified
Last Updated
2026-03-25
Healthy Volunteers
No
Conditions
Locations (1)
National Institutes of Health Clinical Center
Bethesda, Maryland, United States