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Randall's Plaque Study: Pathogenesis and Relationship to Nephrolithiasis
Sponsor: Indiana Kidney Stone Institute
Summary
Kidney stones are very common. They affect 3-5% of the population in the United States. Many people are hospitalized for the treatment of kidney stones and some may die. Better understanding of what causes kidney stones is useful in both the treatment and prevention of kidney stones. However, exactly what causes kidney stones is unknown. The most common type of kidney stones contains calcium, which sometimes is attached to a part of the kidney important in producing the final urine, called the papilla. The investigators have noticed that persons who form kidney stones seem to have more papilla with stones attached. They propose to study these areas of the papilla, called Randall's plaques (named after their discoverer), in patients undergoing surgery for kidney stones.
Official title: Randall's Plaques: Pathogenesis and Relationship to Nephrolithiasis
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
600
Start Date
1998-11
Completion Date
2025-12
Last Updated
2025-01-23
Healthy Volunteers
No
Interventions
videotape for mapping of renal anatomy and papillary biopsy
Subjects who enroll in this study will have their renal anatomy videotaped for mapping purposes. Stone location and characteristics will be documented as will papilla and calyces. One or more papillary biopsies will be taken for analysis.
Locations (1)
IU Health North Hospital
Indianapolis, Indiana, United States