Clinical Research Directory

Inclusion Criteria: * Unilateral or bilateral unresectable primary or metastatic lung tumors \<= 40 mm and a number of tumor \<=5 * Tumors located more than 1 cm from the hilum, and not involving soft tissues or mediastinum. * Malignancy histologically proven for pulmonary nodules in patients with no history of cancer outside the lung. * Lung tumors in patients with a known distant cancer history, has to be either histologically proven or a demonstrated change in size of at least 25% in their largest diameter is required on CT during the previous year * Pretreatment imaging work-up within 4 weeks of scheduled RF ablation (at least a chest CT and an abdomino-pelvic CT) * If a tumor is found outside the lung, it has to be amenable to complete eradication with RF or RF plus surgery * Lung spirometry within 4 weeks of treatment with a FEV1 \>= 1 liter * Written informed consent. Exclusion Criteria: * Uncorrectable coagulopathy with a prothrombin time greater than 1.5 and a platelet count below 106/mm3