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Accelerated Partial Breast Irradiation Following Lumpectomy for Breast Cancer
Sponsor: Stanford University
Summary
To determine whether an accelerated course of radiotherapy delivered to the lumpectomy cavity plus margin using IORT as a single dose, intracavitary brachytherapy with the MammoSite device over 5 days, partial breast 3-D CRT in 5 days, or stereotactic APBI over 4 days is a feasible and safe alternative to a six and a half week course of whole breast radiotherapy. The study will measure both short and long-term complications of radiation treatment, short and long-term breast cosmesis, local rates of in-breast cancer recurrence, regional recurrences, distant metastases, and overall survival.
Key Details
Gender
FEMALE
Age Range
40 Years - Any
Study Type
INTERVENTIONAL
Enrollment
121
Start Date
2002-09
Completion Date
2029-03
Last Updated
2026-03-20
Healthy Volunteers
No
Conditions
Interventions
Intra-Operative Radiotherapy (IORT)
single dose in the operating room after lumpectomy
Lumpectomy
Whole Breast Radiotherapy
six and a half week treatment
Intracavitary Brachytherapy
5 day treatment
Accelerated External Beam 3-D Conformal Radiotherapy
5 day treatment
Stereotactic APBI
4 day treatment
Locations (1)
Stanford University School of Medicine
Stanford, California, United States