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Esophageal Cancer Risk Registry
Sponsor: University of Pittsburgh
Summary
The purpose of this study is to identify markers in the blood and tissue that could indicate risk factors for the development and progression of esophagus cancer. This research aims to collect medical history, blood, and tissue samples from patients who present with an esophageal disorder. Identifying genetic and behavioral risk factors involved in the development of esophageal cancer might allow for early detection and prevention. Survival and an opportunity for a cure with esophageal cancer will depend greatly on the stage of diagnosis. Tumors can develop changes in their genetic (hereditary) make-up, and these changes can sometimes be seen in normal tissues before the development of cancer. These genetic (hereditary) changes can serve as tumor markers and can be detected using methods that study changes in genetic material like DNA and RNA. The analysis of proteins can provide additional information. By identifying changes in these molecules that are different or altered in cancer, the investigators can use methods and tests for the detection of these changes.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
7000
Start Date
1999-06
Completion Date
2050-12
Last Updated
2025-04-16
Healthy Volunteers
No
Conditions
Interventions
Survey of client health, personal habits, family history
A questionnaire is administered at the time of consent.
Blood specimen for non-DNA and DNA parts
Blood specimen is collected prior to surgery or at the time of scheduled routine surgical procedure(s), and at the time of routine follow-up visits
Biopsy of esophageal/stomach tissue, lymph nodes, tumor
Tissue from the biopsies is collected intraoperatively.
Biopsies, oral (saliva) and/or secretions, washings or mucosal scrapings/brushing from routine clinical surveillance endoscopies
Tissue from the biopsies, oral (saliva) and/or secretions, washings or mucosal scrapings/brushings are collected intraoperatively.
Locations (1)
Department of Cardiothoracic Surgery
Pittsburgh, Pennsylvania, United States