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Treatment of Orthostatic Intolerance
Sponsor: Satish R. Raj
Summary
This trial is designed to study the effects of various mechanistically unique medications in controlling excessive increases in heart rate with standing and in improving the symptoms of orthostatic intolerance in patients with this disorder.
Key Details
Gender
All
Age Range
18 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
150
Start Date
1997-04
Completion Date
2029-12
Last Updated
2025-10-08
Healthy Volunteers
Yes
Interventions
Acetazolamide
250 mg PO x 1
Atomoxetine
10-40 mg PO x 1 dose
NO Drug
No intervention - just monitoring
Clonidine
Clonidine 0.05-0.3 mg PO x 1 dose
Entacapone
Entacapone 200-400 mg PO x 1 dose
Entacapone & Propranolol
Entacapone 200-400 mg PO x 1 dose AND propranolol 20 mg PO x 1 dose
Atomoxetine & Propranolol
Atomoxetine 10-40 mg PO x 1 dose AND propranolol 20 mg PO x 1 dose
Indomethacin
Indomethacin 25-50 mg PO x 1 dose
Mecamylamine
mecamylamine 1.25-5 mg PO x 1 dose
Isosorbide Dinitrate
Isosorbide dinitrate 5-20 mg PO x 1 dose
Melatonin
melatonin 3 mg PO x 1 dose
Midodrine
midodrine 2.5-10 mg PO x 1 dose
Modafinil
modafinil 100-200 mg PO x 1 dose
Octreotide
octreotide 12.5-50 mcg Subcutaneous x 1 dose
Placebo
lactose tablet x 1 pill
Propranolol
Propranolol 10-80 mg PO x 1-2 dose
Modafinil & Propranolol
Modafinil 100-200 mg PO x 1 dose AND Propranolol 20 mg PO x 1 dose
Sertraline
sertraline 25-50 mg PO x 1 dose
IV Saline
1 liter IV over 2 hours
Drinking Water
16 fluid ounces
Breathing Device
Breathing through a dead space tube
memantine
memantine 5-20 mg PO x 1 dose
Abdominal binder
Using large blood pressure cuffs linked together, they are wrapped around the subjects abdomen and inflated to generate increased pressure to below tolerably threshold.
Locations (1)
Vanderbilt University Autonomic Dysfunction Center
Nashville, Tennessee, United States