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Study of the Role of PCSK9 and FXR in the Physiopathology of the Joint Dyslipidemia Associated to the Human Immunoresistance
Sponsor: Nantes University Hospital
Summary
Experimental results are strongly suggesting that PCSK9 and FXR could occur in the physiopathology of human joined dyslipidemia. But no data in the literature can validate the potential role of these two genes in the lipidic and glucidic metabolism control in physiopathological situations. This protocol is based on the hypothesis that the expression levels of PCSK 9 and FXR are modified for some patients suffering from insulin resistance and dyslipidemia.
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
111
Start Date
2008-02
Completion Date
2013-11
Last Updated
2026-09-14
Healthy Volunteers
No
Conditions
Interventions
biopsy of muscle, of liver, and of adipose tissue
biopsy of muscle, of liver, and of adipose tissue
clamp euglycemic - hyperglycemic
clamp euglycemic-hyperglycemic
diet
diet
biopsies for biological and genetic analyses
biopsies for biological and genetic analyses
Locations (1)
CHU de Nantes
Nantes, France