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Combined Chemotherapy With or Without Zoledronic Acid for Patients With Osteosarcoma
Sponsor: UNICANCER
Summary
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells. Zoledronic acid may stop the growth of tumor cells in bone. Giving chemotherapy with or without zoledronic acid before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed. Giving these treatments after surgery may kill any tumor cells that remain after surgery. It is not yet known whether giving combination chemotherapy together with zoledronic acid is more effective than combination chemotherapy alone in treating osteosarcoma. PURPOSE: This randomized phase III trial is studying combination chemotherapy and zoledronic acid to see how well they work compared with combination chemotherapy alone in treating patients with osteosarcoma.
Official title: OS2006 : Protocole de Traitement Des ostéosarcomes de l'Enfant, de l'Adolescent et de l'Adulte Comportant
Key Details
Gender
All
Age Range
5 Years - 50 Years
Study Type
INTERVENTIONAL
Enrollment
318
Start Date
2007-03
Completion Date
2026-12
Last Updated
2025-06-08
Healthy Volunteers
No
Conditions
Interventions
cisplatin
doxorubicin hydrochloride
etoposide
ifosfamide
methotrexate
zoledronic acid
conventional surgery
Locations (37)
Centre Paul Papin
Angers, France
Institut Gustave Roussy
Angers, France
Centre Hospitalier Regional de Besancon - Hopital Jean Minjoz
Besançon, France
CHR de Besancon - Hopital Saint-Jacques
Besançon, France
Institut Bergonie
Bordeaux, France
CHU Hopital A. Morvan
Brest, France
CHU de Caen
Caen, France
Centre Regional Francois Baclesse
Caen, France
CHR Clermont Ferrand, Hotel Dieu
Clermont-Ferrand, France
Centre Jean Perrin
Clermont-Ferrand, France
Centre de Lutte Contre le Cancer Georges-Francois Leclerc
Dijon, France
Centre Hospitalier Universitaire de Dijon
Dijon, France
CHU de Grenoble - Hopital Michallon
Grenoble, France
Centre Oscar Lambret
Lille, France
Centre Leon Berard
Lyon, France
Hopital Edouard Herriot - Lyon
Lyon, France
Marseille Institute of Cancer - Institut J. Paoli and I. Calmettes
Marseille, France
CHU de la Timone
Marseille, France
Hopital d'Enfants de la Timone
Marseille, France
CHU Nord
Marseille, France
Hopital Arnaud de Villeneuve
Montpellier, France
Centre Regional de Lutte Contre le Cancer - Centre Val d'Aurelle
Montpellier, France
Centre Antoine Lacassagne
Nice, France
Hopital de l'Archet CHU de Nice
Nice, France
Institut Curie Hopital
Paris, France
Hopital Jean Bernard
Poitiers, France
Centre Eugene Marquis
Rennes, France
Hopital Charles Nicolle
Rouen, France
Centre Henri Becquerel
Rouen, France
Centre Regional Rene Gauducheau
Saint-Herblain, France
Institut de Cancerologie de la Loire
Saint-Priest-en-Jarez, France
Hopitaux Universitaire de Strasbourg
Strasbourg, France
Hopital Universitaire Hautepierre
Strasbourg, France
Hopital des Enfants
Toulouse, France
C.H. Bastien de Clocheville
Tours, France
CHRU de Tours - Hopital Trousseau
Tours, France
Centre Alexis Vautrin
Vandœuvre-lès-Nancy, France