Clinical Research Directory

Inclusion Criteria: 1. Currently meeting DSM-IV criteria for major depressive disorder, recurrent; or major depressive disorder, recurrent, in partial remission; or major depressive disorder, single episode with a duration of 2 years or more; or; dysthymic disorder. 2. Score greater than or equal to 8 on the PHQ at baseline 3. Age greater than or equal to 16 4. Smoking greater than or equal to 5 cigarettes per day 5. Willing to set a quit date within 6 weeks of baseline 6. English speaking and have a telephone 7. Willing to attend all sessions 8. Willing to provide informed consent and agree to all assessments and study procedures Exclusion Criteria: 1. History of psychotic or bipolar disorder 2. Current psychotherapy 3. Current use of antidepressant 4. Current principal DSM-IV Axis I disorder other than unipolar depression or nicotine dependence 5. Involvement in any smoking cessation activities 6. Current use of nicotine replacement therapy 7. Known health or other complications that would adversely affect attendance 8. Severe levels of depressive symptoms, vegetative symptoms, and/or symptoms related to secondary psychiatric disorders that place participant at risk for harm or require immediate treatment 9. Currently at severe or extreme risk of suicide or moderate risk with resolved plans and preparation 10. Medical contraindications for use of nicotine patch, including uncontrolled heart disease, history of severe hypersensitivity to nicotine replacement products, or currently pregnant or lactating 11. 11\) History of current medical condition, or any other factor that, in the judgment of the principal investigator, would likely preclude completion of study requirements.