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Combination Chemotherapy and Nelarabine in Treating Patients With T-cell Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma
Sponsor: M.D. Anderson Cancer Center
Summary
This phase II trial studies the side effects and how well combination chemotherapy and nelarabine work in treating patients with T-cell acute lymphoblastic leukemia or lymphoblastic lymphoma. Drugs used in chemotherapy, such as cyclophosphamide, vincristine, doxorubicin, dexamethasone, methotrexate, cytarabine, mercaptopurine, prednisone, pegaspargase, nelarabine, and venetoclax work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.
Official title: Phase II Study of Hyper-CVAD Plus Nelarabine in Previously Untreated T-ALL and Lymphoblastic Lymphoma
Key Details
Gender
All
Age Range
Any - Any
Study Type
INTERVENTIONAL
Enrollment
160
Start Date
2007-07-11
Completion Date
2026-10-31
Last Updated
2026-01-07
Healthy Volunteers
No
Interventions
Cyclophosphamide
Given IV
Cytarabine
Given IV
Dexamethasone
Given IV or PO
Doxorubicin Hydrochloride
Given IV
Mercaptopurine
Given PO
Methotrexate
Given IV and PO
Nelarabine
Given IV
Pegaspargase
Given IV
Prednisone
Given PO
Venetoclax
Given PO
Vincristine Sulfate
Given IV
Locations (1)
M D Anderson Cancer Center
Houston, Texas, United States