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Effects of Donor and Recipient Genetic Expression on Heart, Lung, Liver, or Kidney Transplant Survival
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Summary
Activity of genes in donor tissues that are involved in inflammation are thought to be involved with early organ dysfunction, increased immune responses in transplant recipients, and organ rejection. The purpose of this study is to determine the relationship between genetic expression in donor and recipient tissue with transplant survival. Participants in this study will have received heart, lung, liver, or kidney transplants.
Official title: Correlation of Donor Proinflammatory mRNA Profiles With Early Outcomes of Thoracic and Abdominal Transplantation
Key Details
Gender
All
Age Range
Any - 70 Years
Study Type
OBSERVATIONAL
Enrollment
313
Start Date
2007-09
Completion Date
2011-08
Last Updated
2026-09-25
Healthy Volunteers
No
Locations (5)
Northwestern Memorial Hospital (kidney and liver)
Chicago, Illinois, United States
Cornell University Medical College (kidney)
Ithaca, New York, United States
Columbia University (lung and liver)
New York, New York, United States
University of Pennsylvania (heart, kidney, liver, lung)
Philadelphia, Pennsylvania, United States
University of Wisconsin (heart and lung)
Madison, Wisconsin, United States