Clinical Research Directory

Does PEP Compensate the Reduction of Tidal Volume During One Lung Ventilation?

Sponsor: University Hospital, Bordeaux

Summary

During general anesthesia, airway closure and the formation of atelectasis impair oxygenation. During one-lung ventilation, large tidal volumes are used to resume atelectasis with a risk of regional over distension and Ventilator-Induced Lung Injury (VILI). The reduction in TV should reduce the occurrence of VILI but lead to a consistent alveolar derecruitment. This harmful effect may be counteracted by PEP. We, therefore, study the impact on oxygenation, of increasing PEP during OLV, in order to maintain alveolar recruitment when TV is reduced.

Official title: Lowering VT and Increasing PEP During One-Lung Ventilation (OLV), Impact on Oxygenation

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