Clinical Research Directory

Inclusion Criteria: * Male or female, 18 - 50 years of age * Requests treatment for cocaine addiction * Meets the DSM-IV criteria for cocaine dependency * Able to provide written informed consent and comply with the study * Females of childbearing potential must have a negative pregnancy test and must be using adequate birth control during the study * Test positive for cocaine on a urinary drug screen * Healthy and medically stable in the opinion of the Principal Investigator Exclusion Criteria: * Liver enzymes greater than two times normal * Any history of hepatitis * History of disorders requiring chronic treatment with steroids * Significantly abnormal ECG * Any prominent DSM-IV axis I disorders other than cocaine dependence * Any subject who presents as a danger to self or others in the opinion of the Principal Investigator * Concomitant use of methamphetamine as determined by self-reporting and verified by measurement of methamphetamine in urinary drug screen * Alcohol consumption greater than 4 drinks per day (1 Drink = 12 oz beer; 5 oz wine; 1.5 oz shot of liquor) * Any clinically significant laboratory test abnormalities * Use of any concomitant medication during the study that would interfere with study medications * Serum cortisol less than 3 µg/dl at any time before or during study * Treatment with an investigational product within 30 days prior to study enrollment * Currently seeking other forms of professional addiction treatment * Known allergic reaction to oxazepam or metyrapone * Lactose intolerance