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Longitudinal Study of Genetic Causes of Intrahepatic Cholestasis (LOGIC)
Sponsor: Arbor Research Collaborative for Health
Summary
Cholestasis is a condition in which bile is not properly transported from the liver to the small intestine. Cholestasis can be caused by an array of childhood diseases, including the genetic diseases Alagille syndrome (ALGS), alpha-1 antitrypsin (a-1AT) deficiency, bile acid synthesis and metabolism defects, and progressive familial intrahepatic cholestasis (PFIC) or benign recurrent intrahepatic cholestasis(BRIC). This study will investigate the natural history and progression of the four previously mentioned cholestatic liver diseases to provide a better understanding of the causes and effects of the diseases.
Key Details
Gender
All
Age Range
Any - 25 Years
Study Type
OBSERVATIONAL
Enrollment
1675
Start Date
2007-11-30
Completion Date
2029-05-31
Last Updated
2026-06-04
Healthy Volunteers
No
Locations (17)
Children's Hospital of Los Angeles
Los Angeles, California, United States
University of California at San Francisco (UCSF)
San Francisco, California, United States
Children's Hospital Colorado
Aurora, Colorado, United States
Children's Healthcare of Atlanta - Emory University
Atlanta, Georgia, United States
Ann & Robert H. Lurie Children's Hospital of Chicago
Chicago, Illinois, United States
Riley Hospital for Children
Indianapolis, Indiana, United States
Johns Hopkins University Hospital
Baltimore, Maryland, United States
St. Louis University - Cardinal Glennon Children's Medical Center
St Louis, Missouri, United States
Washington University School of Medicine/St. Louis Children's Hospital
St Louis, Missouri, United States
Mount Sinai School of Medicine
New York, New York, United States
Cincinnati's Children's Memorial Hospital
Cincinnati, Ohio, United States
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States
UPMC Children's Hospital of Pittsburgh
Pittsburgh, Pennsylvania, United States
Baylor School of Medicine
Houston, Texas, United States
University of Utah
Salt Lake City, Utah, United States
Seattle Children's Hospital
Seattle, Washington, United States
The Hospital for Sick Children
Toronto, Ontario, Canada