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Germline Alterations of Tumor Susceptibility Genes in New York Cancer Patients
Sponsor: Memorial Sloan Kettering Cancer Center
Summary
The basic premise of this research proposal is to determine whether there is any significant association between germline polymorphisms and cancers of colon, bladder, breast, testicular, prostate, ovaries, kidney, lung, lymphoid organs, and head and neck. This is an exploratory study designed to generate hypotheses for further research.
Key Details
Gender
All
Age Range
Any - Any
Study Type
INTERVENTIONAL
Enrollment
21081
Start Date
2000-03
Completion Date
2027-03
Last Updated
2026-04-07
Healthy Volunteers
No
Conditions
Interventions
PCR/PCR/LDR Strategy
Evaluate the extent to which polymorphisms in BRCA1, BRCA2, PTEN, T β R1, TGF β-1, DNA repair genes (including ATM and CHK2), APC, ER, PR, MCP-1, MPIF, CCR2/5 and CCR3 are correlated with cancer incidence. Candidate genes will also be selected from 1) cytokine signaling and 2) apoptosis regulatory pathways.
Locations (1)
Memorial Sloan Kettering Cancer Center
New York, New York, United States