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ACTIVE NOT RECRUITING
NCT00579514
NA

Germline Alterations of Tumor Susceptibility Genes in New York Cancer Patients

Sponsor: Memorial Sloan Kettering Cancer Center

View on ClinicalTrials.gov

Summary

The basic premise of this research proposal is to determine whether there is any significant association between germline polymorphisms and cancers of colon, bladder, breast, testicular, prostate, ovaries, kidney, lung, lymphoid organs, and head and neck. This is an exploratory study designed to generate hypotheses for further research.

Key Details

Gender

All

Age Range

Any - Any

Study Type

INTERVENTIONAL

Enrollment

21081

Start Date

2000-03

Completion Date

2027-03

Last Updated

2026-04-07

Healthy Volunteers

No

Interventions

GENETIC

PCR/PCR/LDR Strategy

Evaluate the extent to which polymorphisms in BRCA1, BRCA2, PTEN, T β R1, TGF β-1, DNA repair genes (including ATM and CHK2), APC, ER, PR, MCP-1, MPIF, CCR2/5 and CCR3 are correlated with cancer incidence. Candidate genes will also be selected from 1) cytokine signaling and 2) apoptosis regulatory pathways.

Locations (1)

Memorial Sloan Kettering Cancer Center

New York, New York, United States