Clinical Research Directory

Inclusion Criteria: * Histologic confirmation of invasive cancer of the female breast in either the primary or metastatic setting * Stage IV disease or stage IIIB disease (using American Joint Committee on Cancer \[AJCC\] criteria, 6th edition) not amenable to local therapy * Patients may not have a "currently active" second malignancy other than non-melanoma skin cancers; patients are not considered to have a "currently active" malignancy if they have completed therapy and are considered by their physician to be at less than 30% risk of relapse * Tumors (from either primary or metastatic sites) must express estrogen receptor (ER) and/or progesterone receptor (PgR) in \>= 1% of cells will be considered positive * Postmenopausal women are eligible for this trial; before study registration, menopausal status must be defined according to the criteria below: * Age \>= 55 years and one year or more of amenorrhea * Age \< 55 years and one year or more of amenorrhea, with an estradiol assay \< 20 pg/ml * For women age \< 55 with prior hysterectomy but intact ovaries, with an estradiol assay \< 20 pg/ml * Surgical menopause with bilateral oophorectomy (at least 28 days must elapse from surgery to time of study registration) * Ovarian suppression on a luteinizing hormone-releasing hormone (LH-RH) agonist * Premenopausal women who do not meet the postmenopausal criteria above are also eligible, but are required to undergo ovarian suppression; this can be initiated any time prior to or on day 1 of protocol therapy, regardless of chosen endocrine therapy, and will continue for the duration of protocol therapy * Patients must have measurable or non-measurable disease by RECIST criteria, with radiologic scans within 28 days of study registration * Measurable disease: lesions that can be accurately measured in at least one dimension (longest diameter to be recorded) as \>= 2.0 cm with conventional techniques or as \>= 1.0 cm with spiral computed tomography (CT) scan * Non-measurable disease: all other lesions, including small lesions (longest diameter \< 2.0 cm with conventional techniques or \< 1.0 cm with spiral CT scan) and truly non-measurable lesions * Lesions that are considered non-measurable include the following: * Bone lesions * Leptomeningeal disease * Ascites * Pleural/pericardial effusion * Inflammatory breast disease * Abdominal masses that are not confirmed and followed by imaging techniques * Cystic lesions * Prior endocrine therapy is not required * Prior endocrine therapy in the metastatic setting is not permitted (unless tamoxifen or an aromatase inhibitor was initiated within 4 weeks prior to registration to facilitate enrollment of patients who recently started first-line endocrine therapy for metastatic breast cancer); if prior letrozole therapy was initiated within the past 4 weeks, the patients should remain on letrozole as the study therapy; patients who began therapy with tamoxifen, anastrozole or exemestane must switch to letrozole to be eligible to participate in this study * Prior endocrine therapy in the adjuvant setting is permitted; there is no time restriction for how long the patient must be on the adjuvant endocrine therapy, nor is there a time restriction for how long the patient needs to be off prior adjuvant endocrine therapy before beginning protocol therapy on 40503 * Prior treatment with ovarian suppression is allowed in either the adjuvant or metastatic setting; if medical ovarian suppression is being administered it can be initiated any time prior to or at the start of protocol therapy, and continued throughout the duration of the trial; surgical castration with bilateral oophorectomy must be performed at least 28 days prior to study registration (due to concerns of poor wound healing on bevacizumab) * Patients may not have received any prior anti-VEGF or VEGFR tyrosine kinase inhibitor therapy * Prior radiotherapy must have been completed and all toxicities resolved at least two weeks prior to registration * Chemotherapy in the adjuvant or neoadjuvant setting is permitted; at least twelve months prior to registration must have elapsed since the completion of adjuvant or neoadjuvant chemotherapy and all toxicities must have resolved; taxane-related neurotoxicity must have resolved to sensory grade \< 2 and no motor neuropathy of any grade is allowed * Patients may have received one prior chemotherapy regimen for metastatic disease; the final dose of prior chemotherapy must have been administered at least 3 weeks prior to study registration * Treatment with bisphosphonates is allowed and recommended as per American Society of Clinical Oncology (ASCO) guidelines * Patients must not have had a major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to study registration, and must have fully recovered from any such procedure * Patients must not have anticipation of need for major surgical procedure during the course of the study * Patients must not have had a core biopsy or other minor surgical procedure, within 7 days prior to study registration; placement of a vascular access device is allowed within 7 days of registration * Patients must not have a history of abdominal fistula, or intra-abdominal abscess within 6 months prior to study registration * Patients with a history of gastrointestinal (GI) perforation within 12 months prior to registration are not eligible * Patients with a history of significant bleeding episodes (e.g., hemoptysis, upper or lower GI bleeding) within 6 months prior to registration are not eligible * Patients must not have clinically significant cardiovascular disease that includes the following: * Uncontrolled hypertension defined as systolic blood pressure \> 150 and/or diastolic blood pressure \> 90 mmHg on antihypertensive medications or any prior history of hypertensive crisis or hypertensive encephalopathy * History of myocardial infarction or unstable angina within past 6 months * New York Heart Association (NYHA) grade 2 or greater congestive heart failure * Symptomatic peripheral vascular disease * Significant vascular disease (e.g., aortic aneurysm, aortic dissection) or arterial thrombotic events * Full dose anticoagulation therapy is allowed for the treatment of prior conditions such as venous thrombosis or atrial fibrillation, but not for the treatment of prior arterial thrombotic events; patients on full dose anticoagulants must be on a stable dose of warfarin and have an in-range international normalized ratio (INR) (usually between 2 and 3) or be on a stable dose of low-molecular weight (LMW) heparin; patients receiving antiplatelet agents are eligible, as are patients on daily prophylactic aspirin or anticoagulation for atrial fibrillation * Patients may not have a history of stroke or transient ischemic attack within 6 months prior to study registration * Patients with a history of seizures must be well controlled with standard medication * Patients must not have known central nervous system (CNS) metastases or leptomeningeal disease (screening with brain imaging is not required for asymptomatic patients) * In aromatase inhibitor (AI)-treated patients: no known allergies to imidazole drugs, (e.g. clotrimazole, ketoconazole, miconazole, econazole, sulconazole, tioconazole, or terconazole) or compounds structurally similar to bevacizumab * In tamoxifen treated patients: no known allergies to selective estrogen receptor modulators (e.g. tamoxifen, raloxifene or toremifene) or compounds structurally similar to bevacizumab; for patients enrolled after Update #5, endocrine therapy will consist of letrozole only and this criterion will no longer apply * Eastern Cooperative Oncology Group (ECOG) (Zubrod) performance status =\< 1 * No serious, non-healing wound, ulcer, or bone fracture * Life expectancy of \>= 12 weeks * All patients who are premenopausal (if not already receiving ovarian suppression therapy/surgical oophorectomy) must have a negative beta-human chorionic gonadotropin (beta-Hcg) prior to starting on study treatment; patients may not be pregnant or nursing at any time during the study; ovarian suppression is required in women of childbearing potential by the start of protocol therapy, and will continue for the duration of protocol therapy * Granulocytes \>= 1,000/ul * Platelet count \>= 100,000/ul * Creatinine =\< 2.0 mg/dL * Bilirubin =\< 1.5 times upper limit of normal (ULN) unless due to Gilbert's syndrome * Transaminases (alanine aminotransferase \[ALT\], aspartate aminotransferase \[AST\]) =\< 2.5 times ULN * International normalized ratio (INR) =\< 1.6, unless on full dose warfarin * Beta-Hcg negative in premenopausal women * Urine protein =\< 1+ or urine to plasma creatinine (UPC) \< 1 * Patients discovered to have \>= 2+ proteinuria at baseline must undergo a 24-hour urine collection that must demonstrate \< 1 g of protein/24 hr, or UPC ratio \< 1 to allow participation in the study