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Pathophysiology of Orthostatic Intolerance
Sponsor: Satish R. Raj
Summary
The purpose of this study is to describe the mechanism of orthostatic intolerance, relying on cardiovascular physiological studies. The syndrome is of undetermined etiology, but the syndrome causes impairment of a number of young adults, females more than males, with symptoms of tachycardia, fatigue, lightheadedness, palpitations, blurred vision, chest discomfort, difficulty concentrating, and dizziness with the upright posture. It is believed that many different pathophysiological processes can give rise to this disorder.
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
260
Start Date
1996-12
Completion Date
2029-12
Last Updated
2025-10-08
Healthy Volunteers
Yes
Interventions
DAXOR
131-I-Human Serum Albumin Blood Volume Assessment Kit
QSweat
Quantitative Sweat Testing
Intrinsic Heart Rate
Atropine 0.04 mg/kg IV in divided doses Propranolol 0.2 mg/kg IV in divided doses
Locations (1)
Vanderbilt University
Nashville, Tennessee, United States