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ACTIVE NOT RECRUITING
NCT00641381
PHASE1

Carmustine, Etoposide, Cyclophosphamide, and Stem Cell Transplant in Treating Patients With HIV-Associated Lymphoma

Sponsor: City of Hope Medical Center

View on ClinicalTrials.gov

Summary

RATIONALE: Giving high-dose chemotherapy drugs, such as carmustine, etoposide, and cyclophosphamide, before a peripheral blood stem cell transplant stops the growth of cancer cells by stopping them from dividing or killing them. After treatment, stem cells that were collected from the patient's blood are returned to the patient to replace the blood-forming cells that were destroyed by the chemotherapy. PURPOSE: This clinical trial is studying the side effects of giving high-dose carmustine, etoposide, and cyclophosphamide together with a stem cell transplant and to see how well it works in treating patients with HIV-associated lymphoma.

Official title: High Dose Chemotherapy and Combination Anti-HIV Therapy for HIV-Associated Hodgkin's and Non-Hodgkin's Lymphoma

Key Details

Gender

All

Age Range

10 Years - 60 Years

Study Type

INTERVENTIONAL

Enrollment

25

Start Date

2000-05-10

Completion Date

2026-02-27

Last Updated

2025-05-01

Healthy Volunteers

No

Conditions

Interventions

DRUG

carmustine

150 mg/m2 day -7, -6,and -5 prior to stem cell reinfusion

DRUG

cyclophosphamide

100 mg/kg on day -2 prior to stem cell reinfusion

DRUG

etoposide

60 mg/kg on day -4 prior to stem cell reinfusion

OTHER

pharmacological study

Prior to start of etoposide infusion, 2 hours after start of infusion, just prior to the end of infusion, then at 0.5, 1, 2, 4, 24 and 48 hours after the end of infusion

PROCEDURE

autologous hematopoietic stem cell transplantation

Reinfusion of autologous stem cells

PROCEDURE

peripheral blood stem cell transplantation

Reinfusion of autologous stem cells

Locations (1)

City of Hope Medical Center

Duarte, California, United States