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Coronary Bypass and Artotic Leaflet Surgery : Heparin Low Dose vs Full Dose
Sponsor: University Hospital, Bordeaux
Summary
The purpose of this study is to demonstrate superiority on postoperative bleeding from the use of a heparin half dose compared to a conventional dose, under mini-extra corporeal circulation, without increased risk to the patient.
Official title: A Prospective Study of Coronary Artery Bypass Graft and/or Aortic Valve Replacement With Conventional Versus Half Heparin Dose Under Closed and Coated Extra Corporeal Circulation System (MECC) - APPACHES Study.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
238
Start Date
2008-06
Completion Date
2013-03
Last Updated
2026-05-19
Healthy Volunteers
No
Interventions
Heparin Low Dose
Loading heparin dose of 150 IU / kg to achieve an ACT (activating clotting time) target more than 240 seconds.
Heparin Full Dose
Loading heparin dose of 300 IU / kg to achieve an ACT (activating clotting time) target more than 400 seconds.
Locations (1)
Cardiac Surgery Dpt (University Hospital)
Bordeaux, France