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Effects of Intravenous Injection of Erythropoietin on Hepcidin Pharmacokinetics in Healthy Volunteers
Sponsor: Rennes University Hospital
Summary
The aim of this study is to measure the variations of serum and urinary hepcidin levels following a single intravenous injection of erythropoietin in healthy volunteers. Hepcidin is a major regulator of iron homeostasis. It acts by binding on ferroportin, and limits cellular efflux of iron through enterocytes and macrophages. Anemia and hypoxia are known to modulate hepcidin synthesis. In these situations, erythropoietin synthesis is increased, so it can be postulated that erythropoietin could modulate hepcidin synthesis.
Key Details
Gender
MALE
Age Range
18 Years - 40 Years
Study Type
INTERVENTIONAL
Enrollment
14
Start Date
2008-02-07
Completion Date
2008-09-30
Last Updated
2026-06-12
Healthy Volunteers
Yes
Conditions
Interventions
Erythropoietin
Intravenous injection of 50 U/kg of erythropoietin
Placebo
Intravenous injection of equivalent volume of saline serum
Locations (1)
Unité d'Investigation Clinique - Centre d'Investigation Clinique - Hôpital de Pontchaillou
Rennes, France