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COMPLETED
NCT00741949
PHASE3

Broncho-alveolar Lavage Under Noninvasive Ventilation With Propofol TCI in Patient With AHRF

Sponsor: University Hospital, Bordeaux

View on ClinicalTrials.gov

Summary

Fiberoptic bronchoscopy (FOB) is an important tool for the diagnosis of pulmonary diseases, more particularly in infectious pneumonia. In patients with severe acute hypoxemic respiratory failure, FOB may be contra-indicated until the patient is intubated and control of its oxygenation obtained. In the literature several authors showed that performing FOB under non invasive ventilation (NIV) preserved oxygenation of the patient; and the recent French Consensus on NIV recommends performing FOB under NIV in patients with acute hypoxemic respiratory failure. Nevertheless this procedure remains uncomfortable in most patients with respiratory failure. In addition, patient's agitation may lead to desaturation, and compromise the realization of FOB.

Official title: Fiberoptic Bronchoscopy With Broncho-alveolar Lavage Under Noninvasive Ventilation With Propofol Target Controled Infusion in Patient With Acute Hypoxemic Respiratory Failure. A Randomized Controlled Study : SEDA-FIBRO.

Key Details

Gender

All

Age Range

18 Years - 90 Years

Study Type

INTERVENTIONAL

Enrollment

46

Start Date

2008-09

Completion Date

2011-06

Last Updated

2026-05-14

Healthy Volunteers

No

Interventions

DRUG

Propofol

Sedation in TCI with propofol

DRUG

Placebo

Isotonic saline solution infusion

Locations (2)

University Hospital Bordeaux, Groupe Hospitalier Pellegrin

Bordeaux, France

Centre hospitalier Libourne

Libourne, France