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COMPLETED
NCT00756080
PHASE1

"Effects of Oral Citrulline on Protein Metabolism in Healthy Humans: a Prospective, Randomized, Double-blind , Cross-over Study" (Citrugrêle)

Sponsor: Nantes University Hospital

View on ClinicalTrials.gov

Summary

The specific aim of this study is to determine whether oral citrulline administration enhances whole body protein synthesis in healthy humans in the postabsorptive state. Protein metabolism will be assessed using an intravenous infusion of stable isotope labeled leucine. The investigators hypothesize that citrulline supplementation will decrease leucine oxidation without altering proteolysis, and consequently stimulate protein synthesis .

Official title: "Effects of Oral Citrulline on Protein Metabolism in Healthy Humans: a Prospective, Randomized, Double-blind , Cross-over Study"

Key Details

Gender

All

Age Range

18 Years - 45 Years

Study Type

INTERVENTIONAL

Enrollment

12

Start Date

2008-09

Completion Date

2009-01

Last Updated

2026-09-14

Healthy Volunteers

Yes

Interventions

DRUG

citrulline

0.06 G/kg three times/day during 7 days

DRUG

placebo

placebo (equimolar mixture of 6 non essential amino acids: alanine, aspartate, glycine, histidine, proline, serine) 0,006 g/kg 3 times/day during 7 days

Locations (1)

CHU Nantes

Nantes, France