Clinical Research Directory

Inclusion Criteria: * Participants diagnosed with cancer; histologically (examination of tissue specimens under a microscope) confirmed malignancy (term for diseases in which abnormal cells divide without control and can invade nearby tissues) * Participants who are able to communicate effectively with study personnel * Participants who have intolerable cancer pain (pain score greater than or equal to \[\>=\] 4) * Participants who have an estimated life expectancy of at least 30 days * Participants who have given written dated informed consent to participate in the study Exclusion Criteria: * Participants who have already received regular treatment with an strong opioid (morphine-like synthetic narcotic that produces the same effects as drugs derived from the opium poppy \[opiates\]), for their pain before entering the study * Participants who have already received tramadol (a narcotic-like pain reliever used to treat moderate to severe pain) treatment over 200 milligram (mg) for their pain before entering the study * Participants with significant abnormalities in hepatic or renal function which would, in the opinion of the Investigator, prevent the participants involvement in the study * Participants with significant clinical abnormalities in central nervous system (CNS), respiratory or cardiovascular function, which in the investigators judgment prevents participation in the study * Pregnant or lactating females or females of child bearing potential not currently practicing documented, adequate contraception