Clinical Research Directory

Inclusion Criteria: 1. Age \> 21 years of age; \< 85 years of age 2. Able to follow instructions 3. Able to provide informed consent 4. Considered clinically stable, with low flow oxygen requirements less than 15 LPM (or FIO2 less than 60 %) and PEEP no greater than 10 cm H2O. 5. Requiring mechanical ventilation through nasal/facial mask,tracheostomy or endotracheal tube (ET Tube) Exclusion Criteria: 1. Clinically unstable, i.e., 1. Acute Respiratory Failure 2. Participants with refractory hypotension defined as systolic blood pressure less than 90 mm Hg despite inotropic agents), 3. Uncontrolled cardiac ischemia or arrhythmias, 4. or as otherwise determined inappropriate for the study as determined by the investigator. 2. Patients suffering from metastatic or terminal cancer and patients with do-not-resuscitate orders 3. Pregnancy