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Sedation Management in Pediatric Patients With Acute Respiratory Failure (The RESTORE Study)
Sponsor: University of Pennsylvania
Summary
People with acute respiratory failure usually require the use of an artificial breathing machine, known as a mechanical ventilator. Sedative medications, which help keep people calm and reduce anxiety, are often prescribed for children who are on mechanical ventilators. However, the longer that sedative medications are used, the longer a child may need to remain on mechanical ventilation. This study will evaluate the effectiveness of a team approach to sedation management that aims to reduce the number of days that children with acute respiratory failure require mechanical ventilation.
Official title: Sedation Management in Pediatric Patients With Acute Respiratory Failure
Key Details
Gender
All
Age Range
2 Weeks - 18 Years
Study Type
INTERVENTIONAL
Enrollment
2449
Start Date
2009-01
Completion Date
2013-12
Last Updated
2026-05-01
Healthy Volunteers
No
Interventions
Team approach to sedation management
The team approach to sedation management includes the following: * Team education and consensus on the use of sedatives * Team identification of the patient's trajectory of illness and daily prescription of a sedation goal * A nurse-implemented goal-directed comfort algorithm that guides moment-to-moment titration of opioids and benzodiazepines * Team feedback on sedation management performance
Usual approach to sedation management
The pediatric ICU will continue its usual approach to sedation management.
Locations (31)
Children's Hospital of Alabama
Birmingham, Alabama, United States
University Medical Center, The University of Arizona
Tucson, Arizona, United States
Children's Hospital and Research Center at Oakland
Oakland, California, United States
Children's Hospital of Orange County
Orange, California, United States
Lucile Salter Packard Children's Hospital at Stanford
Palo Alto, California, United States
University of California Davis Medical Center
Sacramento, California, United States
Children's Hospital at University of California San Francisco Medical Center
San Francisco, California, United States
Connecticut Children's Medical Center
Hartford, Connecticut, United States
Yale-New Haven Children's Hospital
New Haven, Connecticut, United States
Nemours/Alfred I. duPont Hospital for Children
Wilmington, Delaware, United States
Holtz Children's Hospital
Miami, Florida, United States
Florida Hospital for Children
Orlando, Florida, United States
Children's Memorial Hospital, Chicago
Chicago, Illinois, United States
Advocate Hope Children's Hospital
Oak Lawn, Illinois, United States
University of Maryland Hospital for Children
Baltimore, Maryland, United States
Johns Hopkins Children's Center
Baltimore, Maryland, United States
University of Massachusetts Memorial Children's Medical Center
Worcester, Massachusetts, United States
C. S. Mott Children's Hospital of the University of Michigan
Ann Arbor, Michigan, United States
Children's Mercy Hospital, Kansas City
Kansas City, Missouri, United States
St. Louis Children's Hospital
St Louis, Missouri, United States
University of Nebraska Medical Center
Omaha, Nebraska, United States
Dartmouth-Hitchcock Medical Center
Lebanon, New Hampshire, United States
Cohen Children's Medical Center of New York
New Hyde Park, New York, United States
The Children's Hospital at Montefiore
The Bronx, New York, United States
Duke Children's Hospital and Health Center
Durham, North Carolina, United States
Doernbecher Children's Hospital
Portland, Oregon, United States
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States
Monroe Carell, Jr. Children's Hospital at Vanderbilt
Nashville, Tennessee, United States
Medical City Children's Hospital
Dallas, Texas, United States
Children's Medical Center Dallas
Dallas, Texas, United States
Primary Children's Medical Center
Salt Lake City, Utah, United States