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Pharmacokinetics of Antiretroviral Agents in HIV-infected Pregnant Women.
Sponsor: Radboud University Medical Center
Summary
Due to the potential for pregnancy-induced changes in the pharmacokinetics of medication, one cannot assume that the currently licensed doses of the medication to be tested under this protocol lead to adequate exposure in an HIV-infected pregnant woman. For the agents under study no or limited pharmacokinetic data during pregnancy are available. As the changes in pharmacokinetics during pregnancy are most prominent in the third trimester a pharmacokinetic curve will be recorded in the third trimester after attaining steady state.
Official title: Study on Pharmacokinetics of Newly Developed ANtiretroviral Agents in HIV-infected pregNAnt Women (PANNA)
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
176
Start Date
2009-02
Completion Date
2026-12
Last Updated
2025-01-13
Healthy Volunteers
No
Conditions
Locations (21)
Saint-Pierre University Hospital; Department of Infectious Diseases
Brussels, Belgium
CHARITÉ Berlin
Berlin, Germany
University of Bonn
Bonn, Germany
University of Cologne
Cologne, Germany
Johann Wolfgang Goethe-Universität
Frankfurt am Main, Germany
University München
München, Germany
Mater Hospital and UCD
Dublin, Ireland
St James's Hospital Dublin
Dublin, Ireland
IRCSS
Rome, Italy
AMC
Amsterdam, Netherlands
Radboud University Nijmegen Medical Centre
Nijmegen, Netherlands
Erasmus Medical Center Rotterdam
Rotterdam, Netherlands
St Elisabeth hospital
Tilburg, Netherlands
Hospital Universitari Germans Trias i Pujol, Badalona
Badalona, Spain
Hospital Universitario Virgen de las Nieves Granada; Médico Adjunto del Servicio de Medicina Interna
Granada, Spain
Brighton and Sussex University Hospitals NHS Trust
Brighton, United Kingdom
C&W Hospital, London
London, United Kingdom
North Middlesex Hospital
London, United Kingdom
St Mary's Hospital, London
London, United Kingdom
St Thomas Hospital
London, United Kingdom
St. George's Hospital, London
London, United Kingdom