Clinical Research Directory

Inclusion Criteria for Participation in NIRFLI with ICG (Group 1): 1. Negative urine pregnancy test within 36 hours prior to study drug administration, if female of childbearing potential. 2. Females must complete the Female Enrollment Form. Those subjects of childbearing potential must agree to use one of the medically accepted methods of contraception listed on the form for a period of one month following the study. Female subjects of non-childbearing potential, defined as physiologically incapable of becoming pregnant, must meet the criteria listed on the Female Enrollment form, but are not restricted to the use of contraception following study participation. 3. Subjects must be able to lie on their backs for periods of 10 minutes at at time for up to a total of 60 minutes. 4. Children must be able to remain reasonably still for the time required for imaging. 5. Subjects with lymphatic dysfunction must be diagnosed with lymphedema, lipedema, or vascular malformation/anomaly that suggests a lymphatic component. Exclusion Criteria for Participation in NIRFLI with ICG (Group 1): 1. Persons with mobililty issues that could make participating too difficult 2. Women who are pregnant or breast-feeding 3. Persons who are allergic to iodine 4. Persons who weigh in excess of 400 lbs 5. If the subject is a female of child-bearing potential, she must agree to use a contraceptive for one month after study participation. 6. Persons who do not meet inclusion criteria. Inclusion Criteria for Participation in Genetic Analysis Only (Group 2): 1. The subject has a family member with lymphatic dysfunction. 2. The subject is willing to have blood drawn or saliva collected for DNA analysis Exclusion Criteria for Participation in Genetic Analysis Only (Group 2): 1\) The subject has experienced a medical problem from a prior blood draw