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Combination Chemotherapy With or Without Radiation Therapy in Treating Young Patients With Favorable-Risk Hodgkin Lymphoma
Sponsor: St. Jude Children's Research Hospital
Summary
This phase II trial is studying how well combination chemotherapy with or without radiation therapy works in treating young patients with favorable-risk Hodgkin lymphoma. Drugs used in chemotherapy, such as doxorubicin hydrochloride, vinblastine, mechlorethamine hydrochloride, vincristine sulfate, bleomycin, etoposide, and prednisone, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more cancer cells. Radiation therapy uses high-energy x-rays to kill cancer cells for those patients that still had residual cancer at the end of chemotherapy. Giving combination chemotherapy with radiation therapy may kill more cancer cells and allow doctors to save the part of the body where the cancer started.
Official title: Reduced Duration Stanford V Chemotherapy With or Without Low-Dose Tailored-Field Radiation Therapy For Favorable Risk Pediatric Hodgkin Lymphoma
Key Details
Gender
All
Age Range
Any - 21 Years
Study Type
INTERVENTIONAL
Enrollment
88
Start Date
2009-06-05
Completion Date
2028-10
Last Updated
2025-12-08
Healthy Volunteers
No
Conditions
Interventions
Stanford V Chemotherapy
The Stanford V regimen is an abbreviated, multi-agent, dose-intensive regimen that utilizes many of the most active chemotherapy agents for Hodgkin lymphoma: Vinblastine, Doxorubicin, Vincristine, Bleomycin, Mechlorethamine, Etoposide, and Prednisone
Radiation Therapy
Patients who achieve less than a complete response after 8 weeks of chemotherapy will receive 25.5 Gy to individual nodal sites (tailored fields) starting 2-3 weeks following completion of all chemotherapy and recovery of ANC to at least 1000.
Locations (6)
Packard Children's Hospital, Stanford University
Palo Alto, California, United States
Rady Children's Hospital- San Diego
San Diego, California, United States
Children's Hospital of Illinois at OSF St. Francis Medical Center
Peoria, Illinois, United States
Maine Children's Cancer Program (MCCP)
Scarborough, Maine, United States
Dana-Farber Harvard Cancer Center
Boston, Massachusetts, United States
St. Jude Children's Research Hospital
Memphis, Tennessee, United States