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Cranial Radiotherapy or Intensive Chemotherapy With Hematopoietic Stem Cell Rescue for Primary Central Nervous System Lymphoma in Young Patients
Sponsor: Institut Curie
Summary
Purpose of the study : To evaluate the antitumoral effect of two therapeutic procedures and to evaluate their respective toxicity on the CNS.
Official title: Prospective , Multicentric, Randomized Phase II Study, Evaluating the Role of Cranial Radiotherapy or Intensive Chemotherapy With Hematopoietic Stem Cell Rescue After Conventional Chemotherapy for Primary Central Nervous System in Young Patients (< 60 y)
Key Details
Gender
All
Age Range
18 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
140
Start Date
2008-10-03
Completion Date
2026-05
Last Updated
2019-02-05
Healthy Volunteers
No
Conditions
Interventions
cranial radiotherapy
40 Gy
intensive chemotherapy and hematopoietic stem cell rescue
intensive chemotherapy and hematopoietic stem cell rescue
MTX based chemotherapy
R-MBVP 2 cycles day1 and day28 followed by R-Aracytine 2 cycles days58\&59 and days79\&80
Locations (23)
Cancérologie Hôpital Sud
Amiens, France
Chu D'Angers
Angers, France
CHR Argenteuil
Argenteuil, France
CHU de Besancon
Besançon, France
Institut Bergonié
Bordeaux, France
CHU Hôtel Dieu
Clermont-Ferrand, France
CHU Michalon
Grenoble, France
Centre Hospitalier Lens
Lens, France
CHU de Limoges
Limoges, France
CHU de la Timone
Marseille, France
Hôtel Dieu Nantes
Nantes, France
Centre Antoine Lacassagne
Nice, France
CHU de Nimes
Nîmes, France
GH Pitié-Salpétrière
Paris, France
CHG Saint Jean
Perpignan, France
CHU Hôpital Bernard
Poitiers, France
Chu Reims
Reims, France
Hôpital Pontchaillou
Rennes, France
Centre René Huguenin
Saint-Cloud, France
Institut de Cancérologie
Saint-Priest-en-Jarez, France
CH de Saint-Quentin
Saint-Quentin, France
Hôpital Bretonneau
Tours, France
CHU Nancy - Hôpital Neurologique
Vandœuvre-lès-Nancy, France