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COMPLETED
NCT00872625
PHASE1

Radiation Therapy and Docetaxel Followed by Standard Therapy in Treating Women With Breast Cancer

Sponsor: Centre Antoine Lacassagne

View on ClinicalTrials.gov

Summary

RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Giving radiation therapy in higher doses over a shorter period of time may kill more tumor cells and have fewer side effects. Drugs used in chemotherapy, such as docetaxel, epirubicin, cyclophosphamide, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) together with radiation therapy may kill more tumor cells. PURPOSE: This phase I trial is studying the side effects and best dose of radiation therapy when given together with docetaxel followed by standard therapy in treating women with breast cancer.

Official title: Phase I Study - Hypofractionated Cyberknife Radiotherapy Combined With Neoadjuvant Chemotherapy for Breast Tumors

Key Details

Gender

FEMALE

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

26

Start Date

2007-04

Completion Date

2010-12

Last Updated

2026-04-23

Healthy Volunteers

No

Conditions

Interventions

DRUG

cyclophosphamide

DRUG

docetaxel

DRUG

epirubicin hydrochloride

DRUG

fluorouracil

PROCEDURE

neoadjuvant therapy

PROCEDURE

therapeutic conventional surgery

RADIATION

hypofractionated radiation therapy

RADIATION

image-guided radiation therapy

RADIATION

radiation therapy

RADIATION

stereotactic radiosurgery

Locations (1)

Centre Antoine Lacassagne

Nice, France