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Molecular Predictors of Cancer in Patients at High Risk of Lung Cancer
Sponsor: Vanderbilt-Ingram Cancer Center
Summary
RATIONALE: Using samples of blood, urine, sputum, and lung tissue from patients at high risk of cancer for laboratory studies may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer. PURPOSE: This research study is looking at molecular predictors of cancer in patients at high risk of lung cancer.
Official title: Molecular Predictors of Lung Cancer Behavior
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
4000
Start Date
2003-12
Completion Date
2027-01-31
Last Updated
2026-04-27
Healthy Volunteers
No
Conditions
Interventions
comparative genomic hybridization
Collection of sputum, blood, urine, and a small amount of lung tissue.
gene expression microarray analysis
Collection of sputum, blood, urine, and a small amount of lung tissue.
proteomic profiling analysis
Collection of sputum, blood, urine, and a small amount of lung tissue.
biologic sample preservation procedure
Collection of sputum, blood, urine, and a small amount of lung tissue.
nasal brushing
Using a brush, superficial cells are removed from the nose.
Blood draw
Venous blood will be collected
Urine collection
Subjects will be asked to provide a urine specimen.
sputum sample
Prior to their bronchoscopy, subjects will be asked for a sputum specimen. This is a collection of mucous that you cough up.
fluorescence bronchoscopy with airway biopsy
A flexible tube attached to a fluorescent light source will be inserted into the subject's mouth or nose to reach the airway. Samples of the lining of the airway will be taken, as well as bronchial secretions and epithelial cell from brushings of the lining of the airway.
fine needle aspiration of the lung
A small needle is inserted into the lung to collect tissue. This procedure will only be performed if the patient's physician orders it.
thoracentesis
A small needle is inserted into the patient's lung cavity and a small amount of fluid is collected. This procedure will only be performed if the patient's physician orders it.
Locations (2)
Vanderbilt-Ingram Cancer Center
Nashville, Tennessee, United States
Veterans Affairs Medical Center - Nashville
Nashville, Tennessee, United States