Clinical Research Directory

Inclusion Criteria: * patient with skin loss traumatic or chronic wound * wound located from mid third of the leg to distal extremity of feet * with muscle and/or tendon and/or bone and/or articulation exposure * requiring a first surgical intervention for the coverage of the skin loss * patient eligible to the Integra® surgery techniques * patient with social security affiliation * written informed consent signed by the patient or representative Exclusion Criteria: * Bone fracture located in the skin loss * Non traumatic wound * Wound with muscle exposure only * Immunocompromised patient * Allergy to bovine collagen, glycosaminoglycans or silicon * patient with an healthstate that compromise the 18 months Follow-up * pregnant women / who intend to become pregnant within the 18 months of follow-up * Patient under administrative or legal supervision