Clinical Research Directory

Inclusion Criteria for Patients: * Narcoleptic patients with or without cataplexy or hypersomniacs * aged from 18 to 65 years, * treated for attacks of cataplexy, * treated with a maximum dose of Modiodal: 400 mg per day (4 tablets of 100mg), * without any other disease which could be responsible of excessive daytime sleepiness, * having their driver's licence, * driving more than 5000 Km/year, * registered to French national health and pensions organization, * having regular timetables of life 7 days before beginning the study, * having given their written light agreement in order to participate in the study. Inclusion Criteria for Healthy Volunteers: * without any sleep disorders, * having their driver's licence since at least 2 years, * driving more than 5000 Km/year, * registered to French national health and pensions organization, * having regular timetables of life 7 days before beginning the study, * having given their written light agreement in order to participate in the study. Exclusion Criteria for Patients: * Night workers, * breast-feeding or pregnant women * Beck's scale score \< 8, * neurologic disease, * cardiovascular disorders including cardiac arrhythmia, * sleep disorders except narcolepsy and hypersomnia, * pulmonary disorders, * renal disorders, * endocrinal disorders, * having participated in a clinical study during the last 6 months, * unable to drive. Exclusion Criteria for Healthy Volunteers: * Night workers, * neurologic disease, * cardiovascular disorders, * sleep disorders, * pulmonary disorders, * renal disorders, * endocrinal disorders, * having participated in a clinical study during the last 6 months, * unable to drive.