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Imaging of Vesicular Acetylcholine and Dopamine Transporters in Dementia With Lewy Bodies
Sponsor: University Hospital, Bordeaux
Summary
The general aim of this research project is to determine the relationships between alterations of central cholinergic (ACh) and dopaminergic (DA) systems and neurobehavioral features of dementias with Lewy bodies (DLB). Both clinical and neurochemical data support the view that DLB is not a homogeneous entity and it can be hypothesized that differential alterations of central ACh systems (i.e. anterior vs posterior vs striatal interneurons) in association or not with a DA nigrostriatal dysfunction could partly support the clinical heterogeneity observed in this disease. ACh in vivo imaging has been relatively underutilized to date and to our knowledge only on the postsynaptic side. Furthermore, ACh/DA interactions and their relationships with the symptomatology of DLB and related pathologies (PDD) had never been investigated.
Official title: In Vivo SPECT Imaging of Vesicular Acetylcholine and Dopamine Transporters in Dementia With Lewy Bodies: Applying in Diagnostic and Identification of Pathological Subtypes.
Key Details
Gender
All
Age Range
18 Years - 90 Years
Study Type
INTERVENTIONAL
Enrollment
34
Start Date
2009-05
Completion Date
2013-10
Last Updated
2026-05-14
Healthy Volunteers
Yes
Conditions
Interventions
Imaging with IBVM
in vivo molecular imaging of presynaptic molecular target of cholinergic systems with \[123I\]-iodobenzovesamicol
Imaging with DATSCAN
in vivo molecular imaging of presynaptic molecular target of dopaminergic systems (DAT) with DATSCAN
neuropsychological evaluation
neuropsychological evaluation using neuropsychological tests
Locations (1)
Groupe Hospitalier Pellegrin - C.H.U. de Bordeaux
Bordeaux, France