Imaging of Brain Amyloid Plaques in the Aging Population

ENROLLING BY INVITATION

NCT00950430

PHASE4

Sponsor: Mayo Clinic

Summary

This is a prospective, open label, non-therapeutic, diagnostic imaging study. The purpose of this study is to utilize Pittsburgh Compound B positron emission imaging (PiB PET) to ascertain the relationship between change in amyloid burden over time, and concurrent change in clinical status.

Official title: Brain Amyloid Imaging With Pittsburgh Compound B in Normal Aging, Mild Cognitive Impairment, and Dementia

Key Details

Gender

All

Age Range

30 Years - 100 Years

Study Type

INTERVENTIONAL

Enrollment

8000

Start Date

2008-04

Completion Date

2027-06

Last Updated

2025-06-06

Healthy Volunteers

Yes

Conditions

Alzheimer's Disease Dementia With Lewy Bodies Frontotemporal Dementia Vascular Dementia

Interventions

DRUG

Pittsburgh Compound B (C-11 PiB)

Repeat these scans approximately every 24-30 months for up to 10 years in those with all three PETs or 20 years in those with only PiB PET and FDG PET. A second PiB PET, TAU PET and/or FDG PET may be administered within a year if needed to ensure a completed exam for analysis in the rare case of exam failure or data loss.

DRUG

F-18 FDG

Repeat these scans approximately every 24-30 months for up to 10 years in those with all three PETs or 20 years in those with only PiB PET and FDG PET. A second PiB PET, TAU PET and/or FDG PET may be administered within a year if needed to ensure a completed exam for analysis in the rare case of exam failure or data loss.

DRUG

Tau (18-F-AV-1451)

1. PIB PET scan, Tau PET scan and/or FDG PET scan 2. Repeat these scans approximately every 24-30 months for up to 10 years in those with all three PETs or 20 years in those with only PiB PET and FDG PET. A second PiB PET, TAU PET and/or FDG PET may be administered within a year if needed to ensure a completed exam for analysis in the rare case of exam failure or data loss. ECG will be performed on subjects who have not had previous ECG test at Mayo to rule out prolonged QT interval prior to PET TAU scan.

Locations (1)

Mayo Clinic

Rochester, Minnesota, United States

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