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Study of Changes in Skeletal Muscle After Caloric Restriction
Sponsor: Vanderbilt University
Summary
Research has shown that fat stored within muscles affects the muscle's sensitivity to insulin and ability to handle blood glucose. The purpose of this study is to examine the effects of weight loss surgery-induced caloric restriction on the accumulation and types of fats within skeletal muscle, as well as the effects of such caloric restriction on insulin sensitivity and inflammatory responses in skeletal muscle. The investigator proposes that caloric restriction will result in decreases in diacylglycerols enriched with saturated fat and increases in diacylglycerols enriched with monounsaturated fats.
Official title: Diacylglycerols and Insulin Action in Skeletal Muscle Upon Caloric Restriction
Key Details
Gender
FEMALE
Age Range
21 Years - 65 Years
Study Type
OBSERVATIONAL
Enrollment
24
Start Date
2011-03
Completion Date
2026-11
Last Updated
2025-07-08
Healthy Volunteers
Yes
Conditions
Locations (1)
Vanderbilt University Medical Center
Nashville, Tennessee, United States