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Effectiveness of Oral Antibiotics in the Treatment of Severe Acute Malnutrition
Sponsor: Washington University School of Medicine
Summary
The need for oral antibiotics as part of the case management of severe acute malnutrition (SAM) in the outpatient setting has not been studied in a prospective trial. This study will compare the recovery rates of children with SAM treated at home with locally-produced ready-to-use therapeutic food (RUTF) with and without prescribed antibiotics as part of their outpatient case management. The investigators hypothesize that there will be no significant difference in rates of recovery between children who receive and children who do not receive antibiotics.
Official title: Randomized, Double-blind, Placebo-controlled Trial to Evaluate the Effectiveness of Oral Antibiotics in the Community-based Treatment of Severe Acute Malnutrition in Malawian Children
Key Details
Gender
All
Age Range
6 Months - 5 Years
Study Type
INTERVENTIONAL
Enrollment
2767
Start Date
2009-12
Completion Date
2011-05
Last Updated
2026-08-17
Healthy Volunteers
No
Conditions
Interventions
Placebo
liquid placebo medication given twice per day for 7 days
Amoxicillin
liquid amoxicillin given twice per day for 7 days
Cefdinir
liquid cefdinir given twice per day for 7 days
Locations (1)
St. Louis Nutrition Project
Blantyre, Malawi