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COMPLETED
NCT01000298
NA

Effectiveness of Oral Antibiotics in the Treatment of Severe Acute Malnutrition

Sponsor: Washington University School of Medicine

View on ClinicalTrials.gov

Summary

The need for oral antibiotics as part of the case management of severe acute malnutrition (SAM) in the outpatient setting has not been studied in a prospective trial. This study will compare the recovery rates of children with SAM treated at home with locally-produced ready-to-use therapeutic food (RUTF) with and without prescribed antibiotics as part of their outpatient case management. The investigators hypothesize that there will be no significant difference in rates of recovery between children who receive and children who do not receive antibiotics.

Official title: Randomized, Double-blind, Placebo-controlled Trial to Evaluate the Effectiveness of Oral Antibiotics in the Community-based Treatment of Severe Acute Malnutrition in Malawian Children

Key Details

Gender

All

Age Range

6 Months - 5 Years

Study Type

INTERVENTIONAL

Enrollment

2767

Start Date

2009-12

Completion Date

2011-05

Last Updated

2026-08-17

Healthy Volunteers

No

Interventions

DRUG

Placebo

liquid placebo medication given twice per day for 7 days

DRUG

Amoxicillin

liquid amoxicillin given twice per day for 7 days

DRUG

Cefdinir

liquid cefdinir given twice per day for 7 days

Locations (1)

St. Louis Nutrition Project

Blantyre, Malawi