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Impact of Heart Failure on Calcium Homeostasis and Mitochondrial Function in Human Skeletal Muscle
Sponsor: Institut National de la Santé Et de la Recherche Médicale, France
Summary
The aim of this project is to investigate the impact of heart failure (HF) on calcium homeostasis, mitochondrial function and oxidative stress in human skeletal muscle, before and after exercise training. The role playing by circulating factors such as cytokines and catecholamines will also be evaluated. 24 HF patients will be enrolled in the study: 12 class II NYHA HF volunteers with a fraction of ejection between 40% and 30 %, and 12 class III NYHA HF volunteers with a fraction of ejection lower than 30 %. They will be compared to 24 sedentary healthy volunteers, matched on age and physical activity.
Official title: Evaluation of Calcium Homeostasis and Mitochondrial Function in Skeletal Muscle in Subjects With Heart Failure, Before and After Exercise Training
Key Details
Gender
MALE
Age Range
35 Years - 65 Years
Study Type
OBSERVATIONAL
Enrollment
3
Start Date
2010-04
Completion Date
2011-11
Last Updated
2026-10-07
Healthy Volunteers
Yes
Conditions
Locations (1)
Centre Hospitalier Régional Universitaire
Montpellier, France