Tundra Space

Tundra Space

Clinical Research Directory

Browse clinical research sites, groups, and studies.

Back to Studies
COMPLETED
NCT01040637
PHASE1/PHASE2

A Multiple Dose Study of TD-1211 in Healthy Volunteers and Patients With Opioid-Induced Constipation

Sponsor: Glycyx Therapeutics

View on ClinicalTrials.gov

Summary

The purpose of this study is to evaluate the safety, tolerability and pharmacokinetics of TD-1211 in healthy subjects and activity in subjects with opioid-induced constipation (OIC).

Official title: A Phase 1/Phase 2, Randomized, Double-Blind, Multiple Ascending Dose Study to Assess the Safety, Pharmacokinetics, and Effect on Opioid Analgesia of TD-1211 Administered Orally to Healthy Volunteers and to Assess the Safety, Pharmacokinetics, and Effect on Bowel Movements in Subjects With Opioid-Induced Constipation

Key Details

Gender

All

Age Range

18 Years - 65 Years

Study Type

INTERVENTIONAL

Enrollment

102

Start Date

2010-01

Completion Date

2010-10

Last Updated

2026-05-22

Healthy Volunteers

Yes

Interventions

DRUG

TD-1211

Dose level 1

DRUG

TD-1211

Dose level 2

DRUG

TD-1211

Dose level 3

DRUG

TD-1211

Dose Level 4

DRUG

TD-1211

Ascending doses

DRUG

TD-1211

Ascending doses

DRUG

TD-1211

Ascending doses

DRUG

TD-1211

Ascending doses

DRUG

TD-1211

Ascending doses

DRUG

Placebo

Ascending doses

Locations (3)

Clinical Research Unit

Pasadena, California, United States

Clinical Research Unit

San Antonio, Texas, United States

Clinical Research Unit

Salt Lake City, Utah, United States