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Reduced Intensity Conditioning (RIC) Regimen for Patients With Non-malignant Disorders
Sponsor: Children's Hospital of Philadelphia
Summary
This is a Phase II pilot study to evaluate engraftment and toxicity of patients with non-malignant diseases using a reduced intensity conditioning regimen in the setting of allogeneic transplant for non malignant diseases. Bone Marrow or cord blood will be acceptable as a stem cell source. Recently, reduced intensity conditioning (RIC) regimens have been used for both adult patients with leukemias and pediatric patients with non-malignant diseases. These regimens are better tolerated, resulting in less transplant related morbidity and mortality. Stable mixed chimerism, while insufficient for eradication of leukemias, may be sufficient to cure patients with non-malignant diseases.
Key Details
Gender
All
Age Range
6 Months - 25 Years
Study Type
INTERVENTIONAL
Enrollment
75
Start Date
2008-01
Completion Date
2026-12
Last Updated
2024-07-25
Healthy Volunteers
No
Interventions
RIC: Distal Campath
Campath, Fludarabine, Melphalan, Cyclosporine, Cellcept (MMF)
RIC:Intermediate Campath
Campath, Fludarabine, Melphalan, Cyclosporine, Cellcept (MMF)
RIC: Mini Busulfan
Campath, Fludarabine, Busulfan, Cyclosporine, Cellcept (MMF)
Locations (1)
The Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States