Clinical Research Directory
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PRE-DETERMINE Cohort Study
Sponsor: Brigham and Women's Hospital
Summary
This is a prospective, multi-center cohort study of patients with a history of coronary artery disease (CAD) and documentation of either a prior myocardial infarction (MI) or mild to moderate left ventricular dysfunction (LVEF 35-50%). The primary objective of this study is to determine whether biologic markers and ECGs can be utilized to advance SCD risk prediction in patients with CHD and LVEF\>30-35%. The overarching goal of the study is to identify a series of markers that alone or in combination specifically predict risk of arrhythmic death as compared to other causes of mortality among this at risk population of coronary heart disease (CHD) patients with preserved left ventricular ejection fraction (LVEF\> 30-35%). If biologic or ECG markers are identified that can specifically predict risk of ventricular arrhythmias, then these markers may serve as relatively inexpensive methods to identify those at risk. The public health impact of identifying markers could be quite substantial, leading to more efficient utilization of ICDs and advances in our understanding of mechanisms underlying SCD.
Official title: PRE-DETERMINE: Biologic Markers and MRI SCD Cohort Study
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
5764
Start Date
2007-07
Completion Date
2026-11
Last Updated
2025-10-07
Healthy Volunteers
No
Locations (90)
Alaska Heart Institute
Anchorage, Alaska, United States
Phoenix Heart, PLLC
Glendale, Arizona, United States
Cardiovascular Consultants
Phoenix, Arizona, United States
Beaver Medical Group/Clinical Care Research
Banning, California, United States
Memorial Health System
Colorado Springs, Colorado, United States
Colorado Heart and Vascular
Denver, Colorado, United States
Bay Area Cardiology Associates, P.A.
Brandon, Florida, United States
University of Florida - Gainsville
Gainesville, Florida, United States
Reliable Clinical Research
Miami, Florida, United States
Mount Sinai Medical Center
Miami Beach, Florida, United States
Florida Hospital
Orlando, Florida, United States
Orlando Regional Medical Center
Orlando, Florida, United States
Palm Beach Gardens Research Center
Palm Beach Gardens, Florida, United States
Velella Research
Sarasota, Florida, United States
Tallahassee Research Institute, Inc.
Tallahassee, Florida, United States
Cardiology Associates of Palm Beach - West Palm Beach
West Palm Beach, Florida, United States
Georgia Heart Specialist
Covington, Georgia, United States
Northeast Georgia Heart Center, P.C.
Gainesville, Georgia, United States
University of Chicago
Chicago, Illinois, United States
Advocate Medical Group
Chicago, Illinois, United States
Advocate Medical Group - Heart and Vascular of IL
Chicago, Illinois, United States
Consultants in Cardiovascular Medicine
Melrose Park, Illinois, United States
Community Heart and Vascular
Anderson, Indiana, United States
Iowa Heart Center
West Des Moines, Iowa, United States
The University of Kansas
Kansas City, Kansas, United States
Baptist Health Lexington
Lexington, Kentucky, United States
Leonard J. Chabert Medical Center
Houma, Louisiana, United States
Maine Research Associates
Auburn, Maine, United States
Maine Research Associates - Lewiston
Lewiston, Maine, United States
University of Maryland Medical Center
Baltimore, Maryland, United States
Primary Care Cardiology Research
Ayer, Massachusetts, United States
Brigham and Women's Hospital
Boston, Massachusetts, United States
NECCR Internal Medicine and Cardiology Associates, LLC
Fall River, Massachusetts, United States
Hawthorn Medical Associates
North Dartmouth, Massachusetts, United States
Baystate Cardiology
Springfield, Massachusetts, United States
University of Michigan Medical Center
Ann Arbor, Michigan, United States
Oakwood Hospital & Medical Center
Dearborn, Michigan, United States
McLaren Medical Center - Macomb
Mount Clemens, Michigan, United States
Michigan Heart
Ypsilanti, Michigan, United States
Minneapolis VA Medical Center
Minneapolis, Minnesota, United States
University of Missouri Health Care
Columbia, Missouri, United States
Glacier View Cardiology
Kalispell, Montana, United States
The Cardiac Center of Creighton University
Omaha, Nebraska, United States
Advanced Heartcare, LLC
Bridgewater, New Jersey, United States
St. Joseph Regional Medical Center
Paterson, New Jersey, United States
New Mexico VA Healthcare Systems
Albuquerque, New Mexico, United States
Albany Associates Cardiology
Albany, New York, United States
Maimonides Medical Center
Brooklyn, New York, United States
Buffalo General Hospital/Kaleida Health
Buffalo, New York, United States
Jamaica Hospital Medical Center
Jamaica, New York, United States
Mid-Valley Cardiology
Kingston, New York, United States
Winthrop-University Hospital
Mineola, New York, United States
Gotham Cardiovascular
New York, New York, United States
Columbia University Health Center
New York, New York, United States
Stony Brook University Medical Center
Stony Brook, New York, United States
St. Elizabeth Medical Center - Hotvedt
Utica, New York, United States
Asheville Cardiology Associates
Asheville, North Carolina, United States
Eastern Carolina Cardiovascular
Elizabeth City, North Carolina, United States
Northstate Clinical Research
Lenoir, North Carolina, United States
Pinehurst Medical Clinic, Inc.
Pinehurst, North Carolina, United States
Sanford Cardiology
Sanford, North Carolina, United States
Wake Forest
Winston-Salem, North Carolina, United States
Northeast Ohio Cardiovascular Specialists
Akron, Ohio, United States
University of Cincinnati
Cincinnati, Ohio, United States
MetroHealth Medical Center
Cleveland, Ohio, United States
North Ohio Research, Ltd.
Elyria, Ohio, United States
Mercy Medical Associates
Fairfield, Ohio, United States
Northwest Ohio Cardiology Consultants/The Toledo Hospital
Toledo, Ohio, United States
Oklahoma City VA Medical Center Veterans Research and Education Foundation
Oklahoma City, Oklahoma, United States
Oklahoma Foundation for Cardiovascular Research
Oklahoma City, Oklahoma, United States
Abington Memorial Hospital
Abington, Pennsylvania, United States
St. Luke's Bethlehem
Bethlehem, Pennsylvania, United States
Doylestown Cardiology Associates
Doylestown, Pennsylvania, United States
Allegheny General Hospital
Pittsburgh, Pennsylvania, United States
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, United States
AnMed Health
Anderson, South Carolina, United States
VA Medical Center - Charleston
Charleston, South Carolina, United States
Carolina Cardiology Associates
Rock Hill, South Carolina, United States
Black Hills Cardiovascular Research
Rapid City, South Dakota, United States
Cardiovasular Research of Knoxville
Knoxville, Tennessee, United States
Memphis VA Medical Center
Memphis, Tennessee, United States
St. Luke's Episcopal Hospital
Houston, Texas, United States
Non-Invasive Cardiovascular PA
Houston, Texas, United States
Providence Health Center
Waco, Texas, United States
Intermountain Medical Center
Murray, Utah, United States
Cardiovascular Associates Virginia Beach
Virginia Beach, Virginia, United States
University of Alberta
Edmonton, Alberta, Canada
Vancouver General Hospital
Vancouver, British Columbia, Canada
Mississauga Clinical Research Centre
Mississauga, Ontario, Canada
Transcatheter Medical, Inc. Centro Cardiovascular de Caguas y del Caribe
Rio Piedras, Puerto Rico