Clinical Research Directory

Inclusion Criteria: * Age ≥ 12 months and ≤ 6 years * Diagnosis: Spastic cerebral palsy with diplegia, hemiplegia, or quadraplegia. * Performance status: Gross Motor Function (GMF) Classification Score levels II - IV or GMF Score leve I, age \>/= 2 years Spastic hemiplegia: GMF Score II-IV or minimal functional capabilities in the affected upper extremity. A subject classified as GMFCS level I with significant upper extremity impairment will be eligible if the affected upper extremity is used as an assist only. An eligibility committee will meet to review the child's records and determine eligibility. Bilateral hypotonic CP (diplegia or quadriplegia): GMF Score II-IV and an abnormal brain MRI suggestive of an acquired etiology (versus a genetic etiology or brain malformation). * Autologous umbilical cord blood available at a private or public cord blood bank with a minimum total nucleated cell dose of ≥ 1 x 107 cells/kilogram. * Parental consent. Exclusion Criteria: * Athetoid cerebral palsy. * Autism and autistic spectrum disorders without motor disability. * Hypsarrhythmia. * Intractable seizures causing epileptic encephalopathy. * Evidence of a progressive neurologic disease. * Known HIV or uncontrolled bacterial, fungal, or viral infections. * Impaired renal or liver function as determined by serum creatinine \>1.5mg/dL and/or total bilirubin \>1.3mg/dL. * Head circumference \>3 standard deviations below the mean for age. * Known genetic disease or phenotypic evidence of a genetic disease on physical examination. * Concurrent genetic or acquired disease or comorbidity(ies) that could require a future allogeneic stem cell transplant. * Requires ventilatory support, including home ventilator, CPAP, BiPAP, or supplemental oxygen. * Patient's medical condition does not permit safe travel. * Previously received any form of cellular therapy. * Autologous umbilical cord blood unit has any of the following: 1. Total nuclear cell dose \< 1 x 107 cells/kilogram 2. Positive maternal infectious disease markers (except CMV) 3. Evidence of infectious contamination of the cord blood unit 4. Lack of a test sample to confirm identity 5. Evidence of a genetic disease * Unable to obtain parental consent.