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A Pilot Study to Identify Biomarkers Associated With Chronic Traumatic Brain Injury
Sponsor: The University of Texas Health Science Center, Houston
Summary
The aim of this research is to determine if the biological fluids (blood/saliva) from chronic brain-injured patients (both blast and non-penetrating TBI) contain reproducible protein markers. To accomplish this two populations of chronic TBI patients who are receiving treatment at The Institute for Research and Rehabilitation (TIRR): blast injury victims and non-penetrating TBI will be studied. Using multiple proteomic approaches including mass spectrometry, multiplex ELISAs, and antibody microarrays, as well as RNA profiling, the investigators aim to identify biomarkers in the blood/saliva of patients suffering from chronic TBI and to determine the similarities/differences between the blast and non-penetrating injury groups. Identification of these biochemical changes will give insight into the long-lasting changes associated with head injury, and may identify new targets for treating the associated pathologies.
Official title: A Pilot Study to Identify Biomarkers Associated With Chronic TBI
Key Details
Gender
All
Age Range
18 Years - 70 Years
Study Type
OBSERVATIONAL
Enrollment
96
Start Date
2010-04
Completion Date
2016-03-03
Last Updated
2026-06-16
Healthy Volunteers
Yes
Conditions
Interventions
Blood/saliva sampling
one-time blood sample (\~ 1 TBS) and saliva sample (\~ 1 tsp)
Locations (1)
TIRR
Houston, Texas, United States