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Exercise Endothelial Progenitor Cells (EPCs) and Type 2 Diabetes
Sponsor: Baltimore VA Medical Center
Summary
The discovery of the role of endothelial progenitor cells (EPCs) and their involvement in the cardiovascular complications of type 2 diabetes (T2DM) would quickly have a significant impact on the millions of Americans who have T2DM. This project is designed to 1) determine the mechanisms underlying EPC dysfunction in older, sedentary adults with T2DM compared those with normal glucose metabolism and impaired glucose metabolism, and 2) determine if aerobic exercise training is an efficacious therapy for EPC dysfunction in T2DM, and whether improvement in EPC number and function translates to improved endothelial function, increased capillarization, and improved glucose metabolism in T2DM.
Official title: Exercise Training, CACs, and Vascular Function in Older Veterans With IGT (Impaired Glucose Tolerance)
Key Details
Gender
All
Age Range
50 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
70
Start Date
2011-07
Completion Date
2026-12-31
Last Updated
2025-09-19
Healthy Volunteers
Yes
Conditions
Interventions
Aerobic Exercise Training
6 months of aerobic exercise training, 3 days per week
Locations (1)
Baltimore VA Medical Center
Baltimore, Maryland, United States