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Focal Therapy for Prostate Cancer Using HIFU
Sponsor: University College, London
Summary
RATIONALE: Prospective trials using hemi-ablation with high intensity focused ultrasound (HIFU) (Sonablate 500) have demonstrated feasibility, safety, and encouraging functional outcomes and early cancer control with 90% of men achieving trifecta status (no erectile dysfunction, leak-free pad-free continence, cancer control). However, these trials have involved small numbers of patients with men selected for good baseline function. A multi-centre prospective trial within a larger cohort of men that better represents the patient population with prostate cancer (external validity) is required.
Official title: A Multi-Center Prospective Single Arm Intervention Trial Evaluating Focal Therapy Using High Intensity Focused Ultrasound (Sonablate 500) for Localized Prostate Cancer
Key Details
Gender
MALE
Age Range
Any - 90 Years
Study Type
INTERVENTIONAL
Enrollment
354
Start Date
2011-06-29
Completion Date
2029-06
Last Updated
2018-04-20
Healthy Volunteers
No
Interventions
questionnaire administration
assessment of therapy complications
high-intensity focused ultrasound ablation
multiparametric magnetic resonance imaging
quality-of-life assessment
transperineal prostate biopsy
transrectal prostate biopsy
Locations (1)
University College London
London, England, United Kingdom