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Role of Fibrocytes in Chronic Obstructive Pulmonary Disease
Sponsor: University Hospital, Bordeaux
Summary
Chronic obstructive pulmonary disease (COPD) is a frequent airway disease characterized by both bronchial inflammation and remodelling. Bronchial mucosa is infiltrated by macrophages, neutrophils and lymphocytes. In addition, the number of eosinophils can be also increased during exacerbation. Airway remodelling is an abnormal tissue repair following bronchial inflammation, which contributes to none reversible pathological features, such as bronchial and peri-bronchial fibrosis. It also influences the prognosis of COPD and its mechanisms remain largely unknown. The role of fibrocytes has been demonstrated in the pathophysiology of asthma, lung fibrosis or pulmonary hypertension. However, the recruitment of blood fibrocytes and their involvement in COPD airway remodelling remain unknown.
Official title: Role of Fibrocytes in the Bronchial Remodeling of Chronic Obstructive Pulmonary Disease
Key Details
Gender
All
Age Range
40 Years - Any
Study Type
INTERVENTIONAL
Enrollment
115
Start Date
2011-03-11
Completion Date
2016-05-31
Last Updated
2026-06-09
Healthy Volunteers
Yes
Conditions
Interventions
blood sample
blood sample for fibrocytes analysis
Clinical and functional evaluation
Plethysmography, Carbon monoxide capacity of transfer , arterial gaz
Locations (1)
CHU de Bordeaux
Pessac, France