Clinical Research Directory
Browse clinical research sites, groups, and studies.
Nephrotic Syndrome Study Network
Sponsor: University of Michigan
Summary
Minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), and Membranous nephropathy (MN), generate an enormous individual and societal financial burden, accounting for approximately 12% of prevalent end stage renal disease (ESRD) cases (2005) at an annual cost in the US of more than $3 billion. However, the clinical classification of these diseases is widely believed to be inadequate by the scientific community. Given the poor understanding of MCD/FSGS and MN biology, it is not surprising that the available therapies are imperfect. The therapies lack a clear biological basis, and as many families have experienced, they are often not beneficial, and in fact may be significantly toxic. Given these observations, it is essential that research be conducted that address these serious obstacles to effectively caring for patients. In response to a request for applications by the National Institutes of Health, Office of Rare Diseases (NIH, ORD) for the creation of Rare Disease Clinical Research Consortia, a number of affiliated universities joined together with The NephCure Foundation the NIDDK, the ORDR, and the University of Michigan in collaboration towards the establishment of a Nephrotic Syndrome (NS) Rare Diseases Clinical Research Consortium. Through this consortium the investigators hope to understand the fundamental biology of these rare diseases and aim to bank long-term observational data and corresponding biological specimens for researchers to access and further enrich.
Official title: Nephrotic Syndrome Study Network Under the Rare Diseases Clinical Research Network
Key Details
Gender
All
Age Range
Any - 80 Years
Study Type
OBSERVATIONAL
Enrollment
1200
Start Date
2010-04
Completion Date
2029-06-30
Last Updated
2025-04-24
Healthy Volunteers
No
Interventions
Kidney Biopsy
Patients scheduled to undergo a clinically indicated kidney biopsy will be requested to consent to an additional renal core, to be set aside until all clinical care is complete.
Locations (44)
University of Southern California-Children's Hospital
Los Angeles, California, United States
Stanford University School of Medicine
Palo Alto, California, United States
University of California San Francisco Benioff Children's Hospitals
San Francisco, California, United States
Lundquist Biomedical Research Institute at Harbor UCLA Medical Center
Torrance, California, United States
Children's Hospital Colorado
Aurora, Colorado, United States
University of Colorado Anschutz School of Medicine
Aurora, Colorado, United States
University of Miami Miller School of Medicine
Miami, Florida, United States
Emory University and Children's Healthcare of Atlanta
Atlanta, Georgia, United States
John Stroger Cook County Hospital
Chicago, Illinois, United States
University of Kansas Medical Center
Kansas City, Kansas, United States
Johns Hopkins Medical Institute
Baltimore, Maryland, United States
Kidney Disease Section, NIDDK, NIH
Bethesda, Maryland, United States
CS Mott Children's Hospital, University of Michigan
Ann Arbor, Michigan, United States
University of Michigan Medical Center
Ann Arbor, Michigan, United States
Mayo Clinic
Rochester, Minnesota, United States
Children's Mercy Hospital
Kansas City, Missouri, United States
Washington University - St Louis
St Louis, Missouri, United States
Cohen Children's Hospital
New Hyde Park, New York, United States
New York University Medical Center
New York, New York, United States
Bellevue Hospital
New York, New York, United States
New York University Veterans Administration
New York, New York, United States
Columbia University Medical Center
New York, New York, United States
Montefiore Medical Center
The Bronx, New York, United States
University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, United States
Atrium Health Levine Children's Hospital
Charlotte, North Carolina, United States
Wake Forest School of Medicine
Winston-Salem, North Carolina, United States
University Hospital Rainbow Babies & Children's Hospital
Cleveland, Ohio, United States
MetroHealth Hospital at Case Western Medical Center
Cleveland, Ohio, United States
Cleveland Clinic
Cleveland, Ohio, United States
The Ohio State University Wexner Medical Center
Columbus, Ohio, United States
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States
University of Pennsylvania
Philadelphia, Pennsylvania, United States
Temple University
Philadelphia, Pennsylvania, United States
Medical University of South Carolina
Charleston, South Carolina, United States
University of Texas-Southwestern
Dallas, Texas, United States
Texas Children's Hospital - Baylor College of Medicine
Houston, Texas, United States
Seattle Children's Hospital
Seattle, Washington, United States
University of Washington
Seattle, Washington, United States
Providence Medical Research Center
Spokane, Washington, United States
York Central Hospital
Richmond Hill, Ontario, Canada
Scarborough Hospital
Scarborough Village, Ontario, Canada
Credit Valley Hospital
Toronto, Ontario, Canada
Sunnybrook Hospital
Toronto, Ontario, Canada
University Health Network
Toronto, Ontario, Canada