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Delivery Room CPAP in Extremely Low Birth Weight Infants
Sponsor: NICHD Neonatal Research Network
Summary
This pilot study was designed to determine the feasibility of randomizing extremely low birth weight (ELBW) infants \<28 weeks' gestation who required resuscitation to one of two resuscitation methods, either: (a) 100% oxygen by facemask and continuous positive airway pressure (CPAP) or positive pressure ventilation (PPV) with positive end-expiratory pressure (PEEP), if the infant required PPV (the intervention group); or (b) 100% oxygen and no CPAP and no PEEP if the infant required PPV (the control group).
Official title: Delivery Room Continuous Positive Airway Pressure/Positive End Expiratory Pressure (CPAP/PEEP) in Extremely Low Birth Weight (ELBW) Infants
Key Details
Gender
All
Age Range
Any - 10 Minutes
Study Type
INTERVENTIONAL
Enrollment
104
Start Date
2002-07
Completion Date
2003-01
Last Updated
2026-07-01
Healthy Volunteers
No
Conditions
Interventions
CPAP/PEEP
Infants received 100% oxygen by facemask and continuous positive airway pressure (CPAP) or positive pressure ventilation (PPV) with positive end-expiratory pressure (PEEP), if the infant required PPV.
Standard management practices
Control infants were treated with 100% oxygen and no CPAP. When a control infant required PPV, no PEEP was used.
Locations (6)
University of Alabama at Birmingham
Birmingham, Alabama, United States
University of California at San Diego
San Diego, California, United States
University of Miami
Miami, Florida, United States
RTI International
Durham, North Carolina, United States
Cincinnati Children's Medical Center
Cincinnati, Ohio, United States
Case Western Reserve University, Rainbow Babies and Children's Hospital
Cleveland, Ohio, United States