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Soluble Forms and Ligands of RAGE in ALI/ARDS (SoLiRAGE).
Sponsor: University Hospital, Clermont-Ferrand
Summary
RAGE, the receptor for advanced glycation end products, is a novel marker of alveolar epithelial type I cell injury. Soluble RAGE (sRAGE) is elevated in the plasma and in the pulmonary edema fluid from patients with ALI/ARDS, but one should acknowledge that the RAGE/NF-B axis is also involved in the pathophysiology of various other conditions. Few data are available about the levels of soluble forms and ligands of RAGE in the setting of ALI/ARDS. The purpose of this observational prospective study is to describe soluble forms (sRAGE, esRAGE) and ligands of RAGE (HMGB-1, S100A12, AGEs) levels in ICU patients with ALI/ARDS.
Official title: Soluble Forms and Ligands of the Receptor for Advanced Glycation End Products (RAGE) in the Pulmonary Edema Fluid and Plasma From ICU Patients With ALI/ARDS : an Observational Prospective Study.
Key Details
Gender
All
Age Range
18 Years - 95 Years
Study Type
OBSERVATIONAL
Enrollment
60
Start Date
2011-01
Completion Date
2013-01
Last Updated
2026-08-07
Healthy Volunteers
No
Locations (1)
CHU Clermont-Ferrand
Clermont-Ferrand, France